An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

Abstract The aim of this study was developed by a simple method including solution mixing cellulose acetate/sodium alginate containing laponite (CA/SA-LAP) hydrogel composites with flexible mechanical, physical, and biological properties for wound healing application. surface the as-prepared CA/SA CA/SA-LAP were characterized Fourier transform infrared spectroscopy (FT-IR) x-ray Diffraction (XRD). influence LAP content (0.1, 0.2, 0.5 wt%), swelling ratio (171.0 ± 7.0, 143.0 4.0, 96.6 2.5), degradation rate (65.7 4.0%, 49.0 5.5%, 19.4 1.4%), mechanical elongation at break from 68.3 6.0% to 148.3 5.6%, morphology investigated. By increasing concentration an average pore size diameter decreased 300 μ m 225 m, 150 75 m. dressing has designated good antimicrobial activity against Staphylococcus aureus Escherichia coli bacteria 95.9 4.0% 98.4 1.5% 24 h 92.3 4.5% 96.4 3.5% 48 h. Furthermore, revealed admirable biocompatibility human osteosarcoma cell line MG-63. Noticeably, MTT assay demonstrated that fibroblast proliferation significantly enhanced on wt% in compared CS/SA 92.6 4.2% Systematic vivo research conducted rat bone defect model. results proved CA/SA-loaded promoted defects, hydrogels. These great potential material nursing care